Wednesday 8 June 2011

Pantoprazole Protonix

Pantoprazole Protonix
Pantoprazole Protonix
Nexium GenericEsomeprazole is in a class of drugs called proton pump inhibitors PPIs which block the production of acid by the stomach. Other drugs in the same class include omeprazole Prilosec lansoprazole Prevacid rabeprazole Aciphex and pantoprazole Protonix. Chemically esomeprazole is very similar to omeprazole. Proton pump inhibitors are used for the treatment of conditions such as stomach and duodenal ulcers gastroesophageal reflux disease GERD and the Zollinger-Ellison syndrome which all are caused by stomach acid. Esomeprazole like other proton-pump inhibitors blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme the production of acid is decreased and this allows the stomach and esophagus to heal. Esomeprazole was approved by the FDA in February 2001.

how to use
For GERD 20 or 40 mg of esomeprazole is given once daily for 4-8 weeks.

For the treatment of H. pylori 40 mg is administered once daily in combination with amoxicillin and clarithromycin for 10 daysEsomeprazole capsules should be administered one hour before meals swallowed whole and should not be crushed or chewed. Patients with difficulty swallowing can open the capsule and mix the pellets with applesauce. The applesauce should not be hot and the pellets should not be chewed or crushed.

side effects
Esomeprazole like other PPIs is well-tolerated. The most common side effects are diarrhea nausea vomiting headaches rash and dizziness. Nervousness abnormal heartbeat muscle pain weakness leg cramps and water retention occur infrequently.

interaction
Esomeprazole potentially can increase the concentration in blood of diazepam Valium by decreasing the elimination of diazepam in the liver. Esomeprazole may have fewer drug interactions than omeprazole.